Indication For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation. Pharmacodynamics Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Trifluoperazine has not been shown effective in the management of behaviorial complications in patients with mental retardation. Mechanism of action Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain- depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.